Mukhopadhyay NK, Price DJ, Kyriakis JM, Pelech S, Sanghera J, Avruch J. An array of insulinactivated, prolinedirected (Ser/Thr) protein kinases phosphorylate the p70 S6 kinase. J Biol Chem. 1992; 267:332535.
Kyriakis JM, App H, Zhang XF, Banerjee P, Brautigan DL, Rapp UR, Avruch J. Raf1 activaes MAP kinasekinase. Nature.1992; 358:417-21.
Price DJ, Grove, JR, Calvo V, Avruch J, Bierer BE. Rapamycin-induced inhibition of the 70-kilodalton S6 protein kinase. Science. 1992; 257:973-7.
Abdel-Hafiz, HAM, Heasley LE, Kyriakis JM, Avruch J, Kroll JM, Johnson GL, Hoeffler JP. Activating transcription factor-2 DNAbinding activity is stimulated by phosphorylation catalyzed by p42 and p54 microtubule-associated protein kinases. Mol Endocrinol. 1992; 6:2079-89.
Sasaki Y, Zhang XF, Nishiyama M, Avruch J, Wands JR. Expression and phosphorylation of insulin receptor substrate 1 during rat liver regeneration. J Biol Chem. 1993; 268:3805-8.
Kyriakis JM, Force TL, Rapp UR, Bonventre JV, Avruch, J. Mitogen regulation of c-Raf-1 protein kinase activity toward mitogen-activated protein kinase-kinase. J Biol Chem. 1993; 268:16909-19.
Grove, JR, Price DJ, Banerjee P, Balasubramanyam A, Ahmad MF, Avruch J. Regulation of an epitope-tagged recombinant Rsk-1 S6 kinase by phorbol ester and erk/MAP kinase. Biochemistry. 1993; 32:7727-38.
Zhang XF, Settleman J, Kyriakis JM, Takeuchi-Suzuki E, Elledge SJ, Marshall MS, Bruder JT, Rapp UR, Avruch J. Normal and oncogenic p21ras binds to the amino -terminal regulatory domain of c-Raf1. Nature. 1993. 364:308-13.
Force T, Bonventre JV, Heidecker G, Rapp U, Avruch J, Kyriakis JM. Enzymatic characteristics of the c-Raf1 protein kinase. Proc Natl Acad Sci USA. 1994; 91:1270-4.
Troppmair, J, Bruder JT, Munoz H, Lloyd PA, Kyriakis J, Banerjee P, Avruch J, Rapp, UR. Mitogen-activated protein kinase/extracellular signal-regulated protein kinase activation by oncogenes, serum, and 12-O-tetradecanoylphorbol-13acetate requires Raf and is necessary for transformation. J Biol Chem. 1994; 269:7030-5.
Kyriakis JM, Banerjee P, Nikolakaki E, Dai T, Rubie EA, Ahmad MF, Avruch J, Woodgett JR. The stress-activated protein kinase subfamily of cJun kinases. Nature. 1994. 369:156-60.
Chuang E, Barnard D, Hettich L, Zhang X-f, Avruch J, Marshall MS. Critical binding and regulatory interactions between Ras and Raf occur through a small, stable N-terminal domain of Raf and specific Ras effector residues.Molec. Cell Biol. 1994; 14:5318-25.
Pombo CM, Bonventre JV, Avruch J, Woodgett JR, Kyriakis JM, Force T. The stress-activated protein kinases are major c-Jun amino-terminal kinases activated by ischemia and reperfusion. J. Biol. Chem. 1994; 269:26546-51.
Sanchez I., Hughes RT, Mayer BJ, Yee K, Woodgett JR, Avruch J, Kyriakis JM. and Zon LI. SAPK or ERK kinase-1 (SEK1) a physiologic activator of the stress-activated protein kinase (SAPK) family of c-Jun N-terminal kinases. Nature. 1994; 372:794-8.
Barnard D, Hettich L, Chuang E, Zhang X-f, Avruch J, Marshall MS. Identification of the sites of interaction between c-Raf-1 and Ras-GTP. Oncogene. 1995; 10:1283-90.
Dai T, Rubie E, Franklin CC, Kraft A, Kyriakis J, Gillespie DAF, Avruch J, Woodgett JR. SAP kinases bind directly to the d domain of c-Jun in resting cells: implications for repression of c-Jun function. Oncogene. 1995; 10:849-55.
Weng Q-P, Andrabi K, Kozlowski MT, Grove JR, Avruch J. Multiple independent inputs are required for activation of the p70 S6 kinase. Molec. Cell Biol. 1995; 15:2333-40.
Weng Q-P, Andrabi K, Klippel A, Kozlowski MT, Williams LT, Avruch J. Phosphatidylinositol-3 kinase signals activation of p70 S6 kinase in situ through site- specific p70 phosphorylation. Proc. Natl. Acad. Sci USA. 1995; 92:5744-8.
Pombo CM, Kehrl JH, Sanchez I, Katz P, Avruch J, Zon LI, Woodgett JR, Force T, Kyriakis J. Activation of the SAP kinase pathway by GC kinase, a human STE20 homolog. Nature 1995; 377:750-4.
Kharbanda S, Saleem A, Shafman T, Emoto Y, Taneja N, Rubin E, Weicheselbaum R, Woodgett J, Avruch J, Kyriakis J, Kufe D. Ionizing radiation stimulates a Grb2-mediated association of the stress-activated protein kinase wiht phosphatidylinositol 3-kinase. J Biol. Chem. 1995; 270:18871-4.
Luo Z, Zhang X-f, Rapp U, Avruch J. Identification of the 14.3.3 zeta domains important for self association and Raf binding. in J. Biol. Chem. 1995; 270:23681-7.
Rana A, Gallo K, Godowski P, Hirai S-i, Ohno S, Zon L, Kyriakis JM, Avruch J. The mixed lineage kinase SPRK phosphorylates and activates the SAPK activator, SEK-1. JBC 1996; 271:19025-8.
Luo Z, Tzivion G, Belshaw PJ, Marshall M, Avruch J. Oligomerization activates c-Raf-1 through a Ras-dependent mechanism. Nature 1996; 383:181-5.
Luo Z, Diaz B, Marshall MS, Avruch J. An intact Raf zinc finger is required for optimal binding to processed Ras, and for Ras-dependent Raf activation in situ. Mol. Cell. Biol. 1997; 17:46-53,
Marti A, Luo Z, Cunningham C, Ohta Y, Hartwig J, Stossel TP, Kyriakis J, Avruch J. ABP- 280 binds the SAPK activator SEK-1, and is required for TNFa activation of SAPK in melanoma cells. J. Biol. Chem. 1997; 272:2620-8.
Hirai SI, Katoh M, Terada M, Kyriakis JM, Zon LI, Rana A, Avruch J. Ohno S.MST/MLK2, a member of the mixed lineage kinase family, directly phosphorylates and activates SEK1, and activator of c-Jun N-terminal kinase/stress-activated protein kinase. J. Biol. Chem. 1997; 272:15167-73.
Hara K, Kazuyoshi Y, Kozlowski MT, Sugimoto T, Andrabi K, Weng Q-P, Kasuga M, Nishimoto I, Avruch J. Regulation of eIF4E BP1 phosphorylation by mTOR. J. Biol. Chem. 1997; 272:26457-63.