Recent publications:


Eberhart, G.P., Mendez, A.J., and MW Freeman. Decreased cholesterol efflux from fibroblasts of a patient without Tangier Disease, but with markedly reduced high density lipoprotein cholesterol levels. J. Clin. Endo. Metabolism 1998:83;836-846.

Andersson LA and MW Freeman. Functional changes in scavenger receptor binding conformation are induced by charge mutants spanning the entire collagen domain. J. Biol. Chem. 1998:273;19592-19601.

Moore KJ, Fabunmi RP, Andersson LP and MW Freeman. In vitro differentiated embryonic stem cell macrophages: a model system for studying atherosclerosis-associated macrophage functions.Arterioscler Thromb Vasc Biol 1998;18:1647-1654.

Chiang N, Gronert K, Clish, CB, O’Brien JA, Freeman MW and C.S. Serhan. Leukotriene B4 receptor transgenic mice reveal novel protective roles for lipoxins and aspirin-triggered lipoxins in reperfusion J Clin Invest 1999; 309-316.

Fabunmi RP, Moore KJ, Libby P, and MW Freeman. Stromelysin-1 (MMP-3) expression driven by a macrophage-specific promoter results in reduced viability in transgenic mice. Atherosclerosis 1999; 148:375-386.

MW Freeman. Effluxed lipids: Tangier Island’s latest export. Proc Natl Acad Sci USA 1999; 96:10950-10952.

Fitzgerald M, Moore KJ, MW Freeman, GL Reed. Lipopolysaccharide induces scavenger receptor-A expression in murine macrophages via a non-transcriptional mechanism. J Immunol. 2000; 164:2692-2700.

Brousseau ME, Schaefer EJ, Dupuis J, Eustace B, Van Eerdewegh P, Yasek-McKenna D, O’Neill G, Eberhart GP, Weiffenbach B, Freeman MW, Brown RH, JZ Gu. Novel mutations in the gene encoding ATP-binding cassette 1 in four Tangier Disease kindreds. J Lipid Res 2000; 41:433-441.

Brousseau M, Eberhart GP, Schaefer EJ and MW Freeman. Cellular cholesterol efflux in heterozygotes for Tangier disease is markedly reduced and correlates with HDL cholesterol and particle size. J Lipid Res 2000; 41:1125-1135.

Moore, KJ,, Andersson LP, Ingalls RR, Monks BG, Li R, Arnaout MA, Golenbock DT, and MW Freeman. Divergent response to LPS and bacteria in CD14 deficient murine macrophages.. J Immunol 2000;165:4272-4280.

Kurt-Jones EA, Popova L, Kwinn L, Tripp RA, Walsh EE, Freeman MW, Golenbock D, Anderson LJ, and R Finberg. The pattern recognition receptors TLR4 and CD14 mediate the innate immune response to respiratory syncytial virus fusion protein. Nature Immunol 2000;1:398-401.

Li, Z, Kako Y, Pang L., Freeman, MW, Glick J, Wang, XW, and IJ Goldberg. Effects of overexpression of the amino terminal fragment of apolipoprotein B on apo B and lipoprotein production. J Lipid Res 2000;41:1912-20.

Wang X, Zeng W, Murakawa M Freeman MW, and B Seed. Episomal segregation of the adenoviral enhancer sequence by conditional genome rearrangement abrogates late viral gene expression adenovirus. J Virol 2000;74:11296-11303..

Moore KJ, Rosen ED, Fitzgerald ML, Randow F, Andersson LP, Altschuler D, Milstone DS, Mortensen RM, Spiegelman BM, and MW Freeman. Role of PPARg in macrophage differentiation and cholesterol uptake. Nature Med. 2001;7:41-47.

Rigotti A and MW Freeman. Manipulating intestinal cholesterol absorption and hepatic cholesterol and bile acid metabolism by activation of deorphanized nuclear receptors. (Commentary) Gastroenterology; 2001, in press.

Fitzgerald ML, Mendez AJ, Moore KJ, Andersson LP, Panjeton HA, and MW Freeman.. ABCA1 contains an N-terminal signal-anchor sequence that translocates the protein’s first hydrophilic domain to the exoplasmic space. J Biol Chem. 2001: in press.