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Jeannie T. Lee, M.D., Ph.D.
Professor of Genetics and Pathology, Harvard Medical School
Molecular Biologist, Massachusetts General Hospital
Investigator, Howard Hughes Medical Institute
Dr. Lee received her AB degree at Harvard University, where she trained with Dr. Nancy Kleckner, and her MD and PhD degrees from the University of Pennsylvania School of Medicine, where she worked with Dr. Robert Nussbaum. She did her clinical training at Massachusetts General Hospital, served as Chief Resident in Pathology, and then became an HHMI Physician Postdoctoral Fellow with Dr. Rudolf Jaenisch at the Whitehead Institute before assuming her present position. Dr. Lee has also been a Basil O'Connor Starter Scholar (March of Dimes) and a Pew Scholar. |
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Montserrat Anguera, Ph.D.
I received my BA in Environmental Chemistry from the University of California, San Diego and then traveled across the country to Ithaca, NY to begin graduate studies at Cornell University. I obtained my PhD in Biochemistry, Molecular, and Cellular Biology from Cornell, and I am currently working as a postdoctoral fellow in Dr. Jeannie Lee's lab. My current research interests include studying X-linked genes involved in meiotic sex chromosome inactivation using mouse embryonic stem cells and knock-out mouse technologies. |
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Mary Donohoe, Ph.D.
My background is in hematology, immmunology, and transcription. Currently, I am interested in how combinatorial transcription factor binding to the X-inactivation center regulates non-coding RNA. |
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Yesu Jeon, Ph.D.
I received both my undergraduate and graduate degrees from Seoul National University in Korea, where I spent most of my time working on DNA replication and cell cycle regulation until I joined the Lee Lab. I am currently interested in chromosome dynamics during and after X-chromosome inactivation (XCI). |
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Elisabeth Larsen, Ph.D.
I obtained my PhD in molecular biology at The University of Oslo, Norway, and work as a post-doctoral fellow on construction and characterization of mice lacking specific DNA repair functions. This year I am a visiting scientist in the Lee Lab and work on spermatogenesis in mice and X-chromosome inactivation in Human Embryonic Stem Cells. |
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Satoshi Namekawa, Ph.D.
I received my PhD from the Tokyo University of Science.
My research and primary interest are in sex chromosome inactivation during spermatogenesis in mice. |
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Leisha Nolen, M.D., Ph.D.
I received my MD/PhD from the University of Pennsylvania after attending Cornell University as an undergraduate. Prior to joining the lab I spent a year and a half as a pediatric resident at the Children’s Hospital Boston. By joining the Lee lab I hope to return to the basic sciences and continue to study the epigenetic regulation of X Chromosome Inactivation. I will be analyzing the intersection of homologous DNA pairing and X chromosome counting and inactivation. When not in the lab I love to explore the outdoors by foot, ski, bike, kayak or on belay.
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Bernhard Payer, Ph.D.
After I completed my undergraduate studies at the University of Vienna, Austria, I moved to the University of Cambridge, UK, where I did my PhD on germ cell specification in mice. During my PhD I became interested in the field of epigenetics and therefore joined the Lee Lab for my PostDoc. My current research is aimed at elucidating the mechanisms of X-chromosome re-activation during early embryogenesis. Outside the lab I can be usually found on my bicycle exploring the surroundings of Boston. |
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Stefan Pinter, Ph.D.
I obtained my PhD in Molecular Biology from Princeton University where I studied helicase function in nuclear and mitochondrial DNA replication and repair. In Dr. Jeannie Lee's lab, I am primarily interested in using genomic tools to examine how sequence context directs trans-acting factors in specifying chromatin states over large chromosomal domains. What role do non-coding RNAs play in this process and can we link specific factors to regulation of somatic or germline development?
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Dagmar Pommereit, Ph.D.
I received my PhD from the Georg-August University of Göttingen in Germany where I undertook live-cell imaging of neurons. My current research focuses on live-cell imaging of the X-chromosome.
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Kavitha Sarma, Ph.D
I received my PhD in Biochemistry from the University of Medicine and Dentistry of New Jersey. During my graduate studies in Dr. Danny Reinberg's lab, I worked on the identification and characterization of histone methyltransferases and their associated proteins. I joined the Lee Lab to continue my studies in the field of chromatin biology. My current interests include mechanisms of Xist RNA silencing and spreading. When not in the lab, I enjoy oil painting, embroidery and gardening.
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Sha Sun, Ph.D.
I received my BS from Peking University in China and obtained my PhD from the University of Chicago, where I studied gene evolution and male reproduction in Drosophila. I then went to UC Berkeley for postdoctoral research on sex determination and female reproduction in Drosophila. Attracted by the commonality and difference between mammalian and fruit fly sex-linked traits, I joined the Lee Lab as a postdoctoral fellow to pursue research in X-chromosome counting.
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Di Tian, M.D., Ph.D.
After receiving my MD (Beijing Medical University), PhD (Northwestern
University), and a residency training (Massachusetts General Hospital, Harvard
Medical School), I joined Dr. Lee's laboratory as a postdoctoral fellow. My
research is on the dynamic regulation of the mouse Xist gene. |
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Eda Yildirim, Ph.D.
After receiving my BSc degree in Biology from the Middle East Technical University in Turkey, I joined the laboratory of Dr. Lutz Birnbaumer at the University of California, Los Angeles where I had my PhD training. My graduate studies were focused on understanding the cellular and physiological roles of molecules, IP3 receptors and TRPC channels, that regulate cytosolic Ca2+ levels. I joined Dr. Lee’s lab as a post-doctoral fellow to pursue my interest in epigenetics by studying the molecular mechanisms that regulate X-chromosome inactivation in mammals and the role of nuclear compartmentalization in this process. |
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LiFeng Zhang, Ph.D.
I obtained my PhD in Biochemistry from Baylor University. I am interested in X chromosome inactivation because it is a phenomenon related with epigenetic regulation, non-coding RNAs and stem cell pluripotency. |
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Jing (Crystal) Zhao, Ph.D.
I received my PhD in biology from Boston University.
Afterward, I joined the Neuroendocrine Unit of MGH studying endocrine neoplasia. I worked on a maternal imprinted gene that encodes a non-coding RNA and developed a strong interest in epigenetics. I joined Dr. Jeannie Lee’s lab to study the epigenetic control of X chromosome inactivation. |
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Yuya Ogawa, Ph.D.
I received my PhD in biology from Osaka University in Japan. I then joined Jeannie's lab as a postdoctoral fellow. After working for about two years in Japan, I am working with Dr. Jeannie Lee again as visiting scientist.
My research interest is how non-coding RNAs are involved in gene silencing in XCI. |
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Janice Ahn
I received my BS from the University of California, Los Angeles (UCLA), and am currently a graduate student in the Molecular and Cellular Biology department at Harvard University.
I am interested in characterizing the kinetics of X-chromosome inactivation.
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Jennifer Erwin
I received my BS from MIT and made the long move across the Charles River where I am currently a graduate student at Harvard Medical School.
I am interested in the mechanism of imprinted X chromosome inactivation and the role of noncoding RNAs in chromatin structure and silencing.
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Rune Ougland, M.D.
I received my MD from the University of Oslo, Norway. During my medical studies I did research on DNA repair. However, in the last years my research has changed focus towards epigenetics and stem cells. Currently I am working in Jeannie Lee's laboratory as a visiting PhD student studying X chromosome inactivation in human embryonic stem cells.
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Susana Silva
I have a BS in Ecology and Animal Behavior from the University of Lisbon,
Portugal. Currently I am doing my PhD research in the Lee Lab studying the
mechanism of X-chromosome inactivation in Human Embryonic Stem Cells. |
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Rebecca Spencer
I received my BS from the University of Washington and am currently an MD/PhD student at Harvard Medical School. I am using a bioinformatics approach to search for regulatory regions for X-chromosome inactivation and chromosome counting.
When I'm not in the lab, you can find me out hiking, cycling, and eating vegetables from a local non-profit farm called The Food Project. |
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Montserrat Michelman Laboratory Manager
I have a B.S. in Chemistry from the University of Barcelona in Spain.
My research career started at McLean Hospital in Belmont, Massachusetts. In 1995, I started working as a Research Specialist/Lab Manager in the Genetics Department in the laboratory of Dr. Philip Leder.
In 2005, I met with Dr. Jeanie Lee, and was happy to start working here in the Lee Lab. My current duties include responsibilities as Lab Manager, and work with hES research projects studying X chromosome inactivation. I enjoy traveling, biking, hiking and cooking.
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Jeanne Jackson Administrative Assistant
I have worked as an administrative assistant in the medical and scientific community in Boston for over 20 years. After 14 years at Children's Hospital, I came to the Massachusetts General Hospital to work for Dr. Jeannie T. Lee. I also work for Dr. Jack Szostak in the Department of Molecular Biology. My outside interests include watercolors, oil painting, music and renovating my condo.
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| Rebecca Boumil Former Research Fellow |
| Tracey Budzinski Former Technician |
| Conrad Cassie Former Technician |
| Dena Cohen Former Graduate Student |
| Jason Conaty Former Research Fellow |
| Amy Deaton Former Undergraduate Student |
| Yoshiro Fukue Former Research Fellow |
| Yoon Han Former Technician |
| Khanh Huynh Former Instructor |
| Lasvanya Kondapalli Former Undergraduate Student |
| Jane Lopilato Former Visiting Scientist |
| Shila Mekhoubad Former Graduate Student |
| Adam Nagy Former Laboratory Manager |
| Yuya Ogawa Former Research Fellow |
| Rebecca Rowntree Former Research Fellow |
| Shinwa Shibata Former Research Fellow |
| Nicholas Stravopolous Former Graduate Student |
| Bryan Sun Former Graduate Student |
| Chia-Lun (Jack) Tsai Former Research Fellow |
| David Warshawsky Former Research Fellow |
| Na Xu Former Graduate Student |
| Erica Yoo Former Technician |
