Note: Clickable links in blue lead to abstracts on PubMed.

2008

Silva SS, Rowntree RK, Mekhoubad S, Lee JT. X-chromosome inactivation and epigenetic fluidity in human embrynic stem cells. Proc. Natl. Acad. Sci., USA 2008, Mar 25; 105(12):4820-5.

2007

Lin H, Gupta V, Vermilyea MD, Falciani F, Lee JT, O’Neill LP, Turner BM.  Dose compensation in the mouse balances up-regulation and silencing of x-linked genes.  PLos Biol. 2007 Dec; 5 (12):e326.

Xu N, Donohoe ME, Silva SS, and Lee, JT.  Evidence that homologous X-chromosome pairing requires transcription and Ctcf protein.  Nature Genet. 2007 Nov;39(11):1390-1396. Epub 2007 Oct 21. PMID 17952071.

Kim S, Namekawa SH,  Niswander LM, Ward JO, Lee JT, Bardwell, VJ, Zarkower D.  A mammal-specific Doublesex homolog associates with male sex chromatin and is required for male meiosis.  PLoS Genet. 2007 3:e62 PMID 17447844.

Namekawa SH, VandeBerg JL, McCarrey JR, and Lee JT.  Sex chromosome silencing in the marsupial male germ line,  Proc. Natl. Acad. Sci., USA 2007, Jun 5; 104(23):9730-5. 

Zhang LF, Huynh KD, and Lee JT.  Perinucleolar targeting of the inactive X during S phase: evidence for a role in the maintenance of silencing.  Cell. 2007 May 18; 129(4):693-706. 

Mikkelsen TS,….Lee JT,….Tok K.  Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.  Nature. 2007 May 10;447(7141):167-11.

Cohen DE, Davidow LS, Erwin JA, Xu N, Warshawsky D, and Lee JT. The DXPas34 repeat regulates random and imprinted X-inactivation. Dev Cell. 2007 Jan;12(1):57-71.

Donohoe ME, Zhang LF, Xu N, Shi Y, and Lee JT.  Identification of a Ctcf cofactor, Yy1, for the X chromosome binary switch. Mol Cell. 2007 Jan 12;25(1):43-56.

Davidow LS, Breen M, Duke SE, Samollow PB, McCarrey JR, and Lee, JT.   The search for a marsupial XIC reveals a break with vertebrate synteny. Chromosome Res. 2007;15(2):137-46. Epub 2007 Mar 5.

2006

Lewis A, Green K, Dawson C, Redrup L, Huynh KD, Lee JT, Hemberger M.Epigenetic dynamics of the Kenq1 imprinted domain in the early embryo. Development. 2006 Nov;133 (21):4203-10.

Rowntree RK, Lee JT. Mapping of DNA replication origins to noncoding genes of the X-inactivation center. Mol Cell Biol. 2006 May;26(10):3707-17.

Namekawa SH, Park PJ, Zhang LF, Shima JE, McCarrey JR, Griswold MD, Lee JT. Postmeiotic sex chromatin in the male germline of mice. Curr Biol. 2006 Apr 4; 16(7):660-7.

Boumil RM, Ogawa Y, Sun BK, Huynh K.D., Lee J.T. Differential methylation of Xite and CTCF sites in Tsix mirrors the pattern of X-inactivation choice in mice. Mol Cell Biol. 2006 Mar;26(6):2109-17.

Sun BK, Deaton AM, Lee JT. A transient heterochromatic state in Xist preempts X inactivation choice without RNA stabilization. Mol Cell. 2006 Mar 3;21(5):617-28.

Xu N, Tsai CL, Lee JT. Transient homologous chromosome pairing marks the onset of X inactivation. Science. 2006 Feb 24;311(5764):1149-52. Epub 2006 Jan 19.

2005

Lee JT. Regulation of X-chromosome counting by Tsix and Xite sequences. Science. 2005 Jul 29;309(5735):768-71.

Lee JT. Sex chromosome inactivation: the importance of pairing. Curr Biol. 2005 Apr 12;15(7):R249-52. Review.

Huynh KD, Lee JT. X-chromosome inactivation: a hypothesis linking ontogeny and phylogeny. Nat Rev Genet. 2005 May;6(5):410-8. Review.

Stavropoulos N, Rowntree RK, Lee JT. Identification of developmentally specific enhancers for Tsix in the regulation of X chromosome inactivation. Mol Cell Biol. 2005 Apr;25(7):2757-69.

Shibata S, Lee JT. Tsix Transcription versus RNA-Based Mechanisms in Xist Repression and Epigenetic Choice. Curr Biol. 2004 Oct 5;14(19):1747-54

Lee JT. X-chromosome inactivation: a multi-disciplinary approach. Semin Cell Dev Biol. 2003 Dec;14(6):311-2. No abstract available.

Huynh KD and Lee JT. Inheritance of a pre-inactivated paternal X-chromosome in early mouse embryos. Nature. 2003 Dec 18;426(6968):857-62. Epub 2003 Dec 7.

Lee, JT. Functional intergenic transcription: a case study of the X-inactivation centre. Philos Trans R Soc Lond B Biol Sci. 2003 Aug 29;358(1436):1417-23; discussion 1423.

Lee JT. Molecular links between X-chromosome inactivation and autosomal imprinting: dosage compensation as an evolutionary impetus for imprinting. Curr Biol. 2003 Mar 18;13(6):R242-54. Review.

Ogawa Y and Lee JT. Xite, X-inactivation intergenic transcription elements that regulate the probability of choice. Mol Cell. 2003 Mar;11(3):731-43.

O'Neill LP, Randall TE, Lavender J, Spotswood HT, Lee JT and Turner BM. X-linked genes in female embryonic stem cells carry an epigenetic mark prior to the onset of X inactivation. Hum Mol Genet. 2003 Aug 1;12(15):1783-90.

Shibata S and Lee JT. Characterization and quantitation of Tsix transcriptional variants: implications for the mechanism of antisense regulation. Hum Mol Genet. 2003 Jan 15;12(2):125-36.

Lee JT. Molecular biology: Complicity of gene and pseudogene. Nature. 2003 May 1;423(6935):26-8. No abstract available.

Ogawa Y and Lee JT. Antisense regulation in X inactivation and autosomal imprinting. Cytogenet Genome Res. 2002;99(1-4):59-65. Review.

Lee JT. Homozygous Tsix mutant mice reveal a sex-ratio distortion and revert to random X-inactivation. Nat Genet. 2002 Sep;32(1):195-200. Epub 2002 Jul 29.

Lee JT. Is X-chromosome inactivation a homology effect? Adv Genet. 2002;46:25-48. Review. No abstract available.

Chao W, Huynh KD, Spencer RJ, Davidow, LS and Lee JT. CTCF, a candidate trans-acting factor for X-inactivation choice. Science. 2002 Jan 11;295(5553):345-7. Epub 2001 Dec 6.

Cohen DE and Lee JT. X-chromosome inactivation and the search for chromosome-wide silencers. Curr Opin Genet Dev. 2002 Apr;12(2):219-24. Review.

Boumil R M and Lee JT. Forty years of decoding the silence in X- chromosome inactivation. Hum Mol Genet. 2001 Oct 1;10(20):2225-32. Review.

Huynh, K.D. and Lee, J.T. Imprinted X-inactivation in eutherians: a model of gametic execution and zygotic relaxation. Curr Opin Cell Biol. 2001 Dec;13(6):690-7. Review.

Stavropoulos N, Lu N and Lee JT.  A functional role for Tsix transcription in blocking Xist RNA accumulation but not in X-chromosome choice. Proc. Natl. Acad. Sci., USA 2001, 98:232-237.

Lee JT. Disruption of imprinted X-inactivation by parent-of-origin effects at Tsix. Cell. 2000 Sep 29;103(1):17-27.

Reizes B, Lee JT and Leder P. (2000) Homologous genomic fragments in the mouse pre-T cell receptor alpha (pTa) and Xist loci. Genomics. 2000 Jan 1;63(1):149-52.

Lee JT, Davidow LS, and Warshawsky D. (1999), Tsix: Identification of a gene antisense to Xist at the X-inactivation center.Nat Genet. 1999 Apr;21(4):400-4.

Lee JT and Lu N. Targeted mutagenesis of Tsix leads to nonrandom X- inactivation.Cell. 1999 Oct 1;99(1):47-57.

Lee JT, Lu N, and Han, Y. Genetic analysis of the X-inactivation center reveals an 80 kb multifunctional domain. Proc Natl Acad Sci U S A. 1999 Mar 30;96(7):3836-41.

Warshawsky D, Stavropoulos N, and Lee JT. Further examination of the Xist promoter switch hypothesis in X-inactivation: Evidence against the existence and function of a Po promoter. Proc Natl Acad Sci U S A. 1999 Dec 7;96(25):14424-9.