Note: Clickable links in blue lead to abstracts on PubMed.

2009

Zhou D, Conrad C, Xia F, Park JS, Payer B, Yin Y, Lauwers GY, Thasler W, Lee JT, Avruch J, Bardeesy N.  Mst1 and Mst2 Maintain Hepatocyte Quiescence and Suppress HepatocellularCarcinoma Development through Inactivation of the Yap1 Oncogene.  Cancer Cell. 2009 Nov 6;16(5):425-38.

Lee JT. Lessons from X-chromosome inactivation: long ncRNA as guides and tethers to the epigenome. Genes Dev. August 15, 2009 23:1831-1842

Donohoe ME, Silva SS, Pinter SF, Xu N, Lee JT. The pluripotency factor Oct4 interacts with Ctcf and also controls X-chromosome pairing and counting. Nature. 2009 July 2; 460:128-132. Epub June 17.

Namekawa SH and Lee JT. XY and ZW: Is meiotic sex chromosome inactivation the rule in evolution? PLoS Genet. 2009 5(5):e1000493.

Zhang L-F, Ogawa Y, Ahn JY, Namekawa SH, Silva SS, and Lee JT. Telomeric RNAs mark sex chromosomes in stem cell .Genetics 2009 July 182:685-689

2008

Zhao J, Sun BK, Erwin JA, Song J-J, Lee TJ. Polycomb proteins targeted by a short repeat RNA to the mouse X-chromosome. Science 2008 Oct. 31; 322(5920):750-756.

Anguera MC, Liu M, Avruch J, Lee JT. Characterization of two Mst1-deficient mouse models. Dev Dyn. 2008 Nov.;237 (11):3424-2334

Shibata S and Lee JT. MacroRNAs in the epigenetic control of X-chromosome inactivation. In: Epigenomics. 2008 (in press).

Payer B and Lee JT. X-chromosome dosage compensation: How mammals keep the balance. Ann. Rev. Genetics 2008 Aug 26.

Lindroth AM, Park YJ, McLean CM, Dokshin GA, Persson JM, Herman H, Pasini D, Miró X, Donohoe ME, Lee JT, Helin K, Soloway PD. Antagonism between DNA and H3K27 methylation at the imprinted Rasgrf1 locus. PLoS Genet. 2008 Aug 1;4(8):e1000145.

Erwin JA and Lee JT.  New twists in X-chromosome inactivation.  Curr. Opin. Cell. Biol.  2008 June;20(3):3349-55. 

Ogawa Y, Sun BK, Lee JT.  Intersection of the RNA interference and X-inactivation pathways.  Science.  2008 June 6;320(5881):1336-1341.

Tsai CL, Rowntree RK, Cohen DE, Lee JT.  Higher order chromatin structure at the X-inactivation center via looping DNA.  Dev.
Biol. 2008 July 15;319(2):416-415.

Silva SS, Rowntree RK, Mekhoubad S, Lee JT. X-chromosome inactivation and epigenetic fluidity in human embrynic stem cells. Proc. Natl. Acad. Sci., USA 2008, Mar 25; 105(12):4820-4825.

2007

Lin H, Gupta V, Vermilyea MD, Falciani F, Lee JT, O’Neill LP, Turner BM.  Dose compensation in the mouse balances up-regulation and silencing of x-linked genes. PLos Biol. 2007 Dec; 5(12):e326.

Xu N, Donohoe ME, Silva SS, and Lee, JT.  Evidence that homologous X-chromosome pairing requires transcription and Ctcf protein.Nature Genet. 2007 Nov;39(11):1390-1396. Epub 2007 Oct 21.

Kim S, Namekawa SH,  Niswander LM, Ward JO, Lee JT, Bardwell, VJ, Zarkower D.  A mammal-specific Doublesex homolog associates with male sex chromatin and is required for male meiosis. PLos Genet. 2007 Apr 20;3(4):e62.

Namekawa SH, VandeBerg JL, McCarrey JR, and Lee JT.  Sex chromosome silencing in the marsupial male germ line.  Proc. Natl. Acad. Sci., USA 2007, Jun 5; 104(23):9730-5.

Zhang LF, Huynh KD, and Lee JT.  Perinucleolar targeting of the inactive X during S phase: evidence for a role in the maintenance of silencing.  Cell. 2007 May 18; 129(4):693-706. 

Mikkelsen TS,….Lee JT,….Tok K.  Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.  Nature. 2007 May 10;447(7141):167-11.

Cohen DE, Davidow LS, Erwin JA, Xu N, Warshawsky D, and Lee JT. The DXPas34 repeat regulates random and imprinted X-inactivation. Dev Cell. 2007 Jan;12(1):57-71.

Donohoe ME, Zhang LF, Xu N, Shi Y, and Lee JT.  Identification of a Ctcf cofactor, Yy1, for the X chromosome binary switch. Mol Cell. 2007 Jan 12;25(1):43-56.

Davidow LS, Breen M, Duke SE, Samollow PB, McCarrey JR, and Lee, JT.   The search for a marsupial XIC reveals a break with vertebrate synteny. Chromosome Res. 2007;15(2):137-46. Epub 2007 Mar 5.

2006

Lewis A, Green K, Dawson C, Redrup L, Huynh KD, Lee JT, Hemberger M, Reik W. Epigenetic dynamics of the Kenq1 imprinted domain in the early embryo. Development. 2006 Nov;133 (21):4203-10.

Rowntree RK, Lee JT. Mapping of DNA replication origins to noncoding genes of the X-inactivation center. Mol Cell Biol. 2006 May;26(10):3707-17.

Namekawa SH, Park PJ, Zhang LF, Shima JE, McCarrey JR, Griswold MD, Lee JT. Postmeiotic sex chromatin in the male germline of mice. Curr Biol. 2006 Apr 4; 16(7):660-7.

Boumil RM, Ogawa Y, Sun BK, Huynh K.D., Lee J.T. Differential methylation of Xite and CTCF sites in Tsix mirrors the pattern of X-inactivation choice in mice. Mol Cell Biol. 2006 Mar;26(6):2109-17.

Sun BK, Deaton AM, Lee JT. A transient heterochromatic state in Xist preempts X inactivation choice without RNA stabilization. Mol Cell. 2006 Mar 3;21(5):617-28.

Xu N, Tsai CL, Lee JT. Transient homologous chromosome pairing marks the onset of X inactivation. Science. 2006 Feb 24;311(5764):1149-52. Epub 2006 Jan 19.

2005

Lee JT. Regulation of X-chromosome counting by Tsix and Xite sequences. Science. 2005 Jul 29;309(5735):768-71.

Lee JT. Sex chromosome inactivation: the importance of pairing. Curr Biol. 2005 Apr 12;15(7):R249-52. Review.

Huynh KD, Lee JT. X-chromosome inactivation: a hypothesis linking ontogeny and phylogeny. Nat Rev Genet. 2005 May;6(5):410-8. Review.

Stavropoulos N, Rowntree RK, Lee JT. Identification of developmentally specific enhancers for Tsix in the regulation of X chromosome inactivation. Mol Cell Biol. 2005 Apr;25(7):2757-69.

Shibata S, Lee JT. Tsix Transcription versus RNA-Based Mechanisms in Xist Repression and Epigenetic Choice. Curr Biol. 2004 Oct 5;14(19):1747-54

Lee JT. X-chromosome inactivation: a multi-disciplinary approach. Semin Cell Dev Biol. 2003 Dec;14(6):311-2. No abstract available.

Huynh KD and Lee JT. Inheritance of a pre-inactivated paternal X-chromosome in early mouse embryos. Nature. 2003 Dec 18;426(6968):857-62. Epub 2003 Dec 7.

Lee, JT. Functional intergenic transcription: a case study of the X-inactivation centre. Philos Trans R Soc Lond B Biol Sci. 2003 Aug 29;358(1436):1417-23; discussion 1423.

Lee JT. Molecular links between X-chromosome inactivation and autosomal imprinting: dosage compensation as an evolutionary impetus for imprinting. Curr Biol. 2003 Mar 18;13(6):R242-54. Review.

Ogawa Y and Lee JT. Xite, X-inactivation intergenic transcription elements that regulate the probability of choice. Mol Cell. 2003 Mar;11(3):731-43.

O'Neill LP, Randall TE, Lavender J, Spotswood HT, Lee JT and Turner BM. X-linked genes in female embryonic stem cells carry an epigenetic mark prior to the onset of X inactivation. Hum Mol Genet. 2003 Aug 1;12(15):1783-90.

Shibata S and Lee JT. Characterization and quantitation of Tsix transcriptional variants: implications for the mechanism of antisense regulation. Hum Mol Genet. 2003 Jan 15;12(2):125-36.

Lee JT. Molecular biology: Complicity of gene and pseudogene. Nature. 2003 May 1;423(6935):26-8. No abstract available.

Ogawa Y and Lee JT. Antisense regulation in X inactivation and autosomal imprinting. Cytogenet Genome Res. 2002;99(1-4):59-65. Review.

Lee JT. Homozygous Tsix mutant mice reveal a sex-ratio distortion and revert to random X-inactivation. Nat Genet. 2002 Sep;32(1):195-200. Epub 2002 Jul 29.

Lee JT. Is X-chromosome inactivation a homology effect? Adv Genet. 2002;46:25-48. Review. No abstract available.

Chao W, Huynh KD, Spencer RJ, Davidow, LS and Lee JT. CTCF, a candidate trans-acting factor for X-inactivation choice. Science. 2002 Jan 11;295(5553):345-7. Epub 2001 Dec 6.

Cohen DE and Lee JT. X-chromosome inactivation and the search for chromosome-wide silencers. Curr Opin Genet Dev. 2002 Apr;12(2):219-24. Review.

Boumil R M and Lee JT. Forty years of decoding the silence in X- chromosome inactivation. Hum Mol Genet. 2001 Oct 1;10(20):2225-32. Review.

Huynh, K.D. and Lee, J.T. Imprinted X-inactivation in eutherians: a model of gametic execution and zygotic relaxation. Curr Opin Cell Biol. 2001 Dec;13(6):690-7. Review.

Stavropoulos N, Lu N and Lee JT.  A functional role for Tsix transcription in blocking Xist RNA accumulation but not in X-chromosome choice. Proc. Natl. Acad. Sci., USA 2001, 98:232-237.

Lee JT. Disruption of imprinted X-inactivation by parent-of-origin effects at Tsix. Cell. 2000 Sep 29;103(1):17-27.

Reizes B, Lee JT and Leder P. (2000) Homologous genomic fragments in the mouse pre-T cell receptor alpha (pTa) and Xist loci. Genomics. 2000 Jan 1;63(1):149-52.

Lee JT, Davidow LS, and Warshawsky D. (1999), Tsix: Identification of a gene antisense to Xist at the X-inactivation center. Nat. Genet. 1999 Apr;21(4):400-4.

Lee JT and Lu N. Targeted mutagenesis of Tsix leads to nonrandom X- inactivation.Cell. 1999 Oct 1;99(1):47-57.

Lee JT, Lu N, and Han, Y. Genetic analysis of the X-inactivation center reveals an 80 kb multifunctional domain. Proc Natl Acad Sci U S A. 1999 Mar 30;96(7):3836-41.

Warshawsky D, Stavropoulos N, and Lee JT. Further examination of the Xist promoter switch hypothesis in X-inactivation: Evidence against the existence and function of a Po promoter. Proc Natl Acad Sci U S A. 1999 Dec 7;96(25):14424-9.