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Recent Publications
1. Shigemitsu K, Tsujishita Y, Hara K, Nanahoshi M, Avruch J, Yonezawa K. Regulation of translational effectors by amino acid and mammalian target of rapamycin signaling pathways. J. Biol. Chem. 1999; 274:1058-65.
2. Isotani S, Hara K, Tokunaga C, Inoue H, Avruch J, Yonezawa K. Immunopurified mammalian target of rapamycin (mTOR) phosphorylates and activates p70 S6 kinase _ in vitro J. Biol. Chem. 1999;274:34408-98.
3. Balendran A, Currie R, Armstrong CG, Avruch J, Alessi DR. Evidence that 3-phosphoinositide-dependent protein kinase-1 mediates phosphorylation of p70 S6 kinase in Vivo at Thr-412 as well as Thr-252. J. Biol. Chem. 1999; 37400-06.
4. Lenz G, Gottfried G, Luo Z, Avruch J, Rodnight R, Nie WJ, Kang Y, Neary JT. P2y purinoreceptor subtypes recruit different Mek activators in astrocytes. Brit. J. Pharmacol. 2000; 129:927-36.
4. Yokogami K, Wakisaka S, Avruch J, Reeves SA. Serine phosphorylation and maximal activation of STAT3 during CNTF signaling is mediated by the rapamycin target mTOR. Curr Biol. 2000; 10:47-50.
6. Tzivion G, Luo Z-L, Avruch J. Calyculin-A-induced vimentin phosphorylation sequesters 14-3-3 and displaces other 14-3-3 partners in vivo. J. Biol. Chem. 2000; 275:29772-8.
7. Belham C, Comb MJ, Avruch J. Identification of the NIMA family kinases NEK6/7 as regulators of the p70 ribosomal S6 kinase. Curr Biol. 2001; 11:1155-1167.
8. Tang H., Hornstein E., Stolovich M., Levy G., Livingstone M., Templeton D., Avruch J., Meyuhas O. Amino-acid induced translation of TOP mRNAs is fully dependent on PI3-kinase-mediated signalling, is partially inhibited by rapamycin, and is independent of S6K1 and rpS6 phosphorylation. Mol Cell Biol. 2001; 21:8671-8683.
9. Ortiz-Vega S, Khokhlatchev S, Nedwidek M, Zhang X-f, Dammann R, Pfeifer GP, Avruch J. The Putative Tumor Suppressor RASSF1A Homodimerizes and Heterodimerizes with the Ras-GTP Binding Protein Nore1. Oncogene, 2002; 21:1381-1390.
10. Wu S, Mikhailov A, Kalloo-Hosein H, Hara K, Yonezawa K, Avruch J. Characterization of Ubiquilin 1, an mTOR-interacting protein. BBA Mol Cell Reg. 2002;1542:41-56.
11. Khokhlatchev A, Rabizadeh S, Xavier R, Nedwidek M, Chen T, Zhang X-f, Seed B, Avruch J. Identification of a novel Ras-regulated proapoptotic pathway. Curr Biol, 2002; 12:253-265.
12. Tommasi S, Damman R, Jin S-G., Zhang X-F., Avruch J., Pfeifer G.P.,RASSF3 and NORE1: Identification and cloning of two human homologues of the putative tumor surpressor gene RASSF1A. Oncogene, 2002; 21.2713-2720
13. Roig J, Mikhailov A, Belham C, Avruch J. Nercc, a mammalian NIMA-family kinase, binds the Ran GTPase and regulates mitotic progression. Genes Dev. 2002;16:1640-58.
14. Hara K, Maruki Y, Long X, Yoshino K, Oshiro N, Hidayat S, Tokunaga C, Avruch J, Yonezawa K. Raptor, a Binding Partner of Target of Rapamycin (TOR), Mediates TOR Action. Cell. 2002;110:177-89.
15. Long X, Spycher C, Han SZ, Rose AM, Muller F, Avruch J. TOR deficiency in C. elegans causes developmental arrest and intestinal atrophy by inhibition of mRNA translation. Curr Biol,2002; 12:1448-1461.
16. Lin Y, Khoklatchev A, Figeys D, Avruch J. Death-Associated Protein 4 binds MST1 and augments MST1-induced apoptosis. J. Biol. Chem.2002; 277: 47991-48001.
17. Nojima H, Hara K, Tokunaga C, Eguchi S, Oshiro N, Hidayat S, Yoshino K-I,Tanaka N, Avruch J, Yonezawa K. The mTOR partner Raptor binds the mTOR substrates, p70 S6 kinase and 4E-BP1 through their TOS (TOR signaling) motif. J. Biol.Chem. 2003;278:15461-4.
18. Shen YH, Godlewski J, Bronisz A, Zhu J, Comb MJ, Avruch J, Tzivion G. Significance of 14-3-3 self-dimerization for phosphorylation-dependent target binding. Mol. Biol. Cell, 2003;14:4721-33
19. Belham C , Roig J, Caldwell JA, Aoyama Y, Kemp BE, Comb M, Avruch J. A mitotic cascade of NIMA-family kinases: Nercc1/Nek9 activates the Nek6 and Nek7 kinases. J. Biol. Chem.,2003; 278:34897-34909.
20. Aoyama Y, Avruch J, Zhang F-X. NORE1 Inhibits Tumor Cell Growth Independent of Ras or the MST1/2 Kinases. Oncogene, in press.
21. Oshiro N, Yoshino K-I, Hidayat S, Tokunaga C, Hara K, Eguchi S, Avruch J, Yonezawa K. Dissociation of Raptor from mTOR is a possible mechanism of rapamycin-induced inhibition of mTOR function. Genes to Cells, in press.
Reviews and Chapters
1. Belham C., Wu S., Avruch J. Intracellular signalling:PDK1 – a kinase at the hub of things. Curr. Biol. Dispatch 1999; 9: R93-R96
2. Avruch, J. Small GTPases and (Serine/Threonine) Protein Kinase Cascades in Insulin Signal Transduction. In Diabetes Mellitus: A Fundamental and Clinical Text. LeRoith D, Olefsky J, Taylor S, ed., J.P. Lippincott Co, Phil, PA, 2000.
3. Avruch, J. Hormone Signaling Via Receptor Tyrosine Kinases. Endocrinology, Fourth Edition. DeGroot L.J. and J. L. Jameson, eds., WB Saunders Company 2001, pp25-48.
4. Kyriakis JM., Avruch J. Mammalian mitogen-activated protein kinase signal Transduction pathways activated by stress and inflammation. Physiologic Reviews. 81: 807-869, 2001.
5. Avruch, J. Khoklatchev, A., Kyriakis. J.M., Luo, Z-J, Tzivion, G., Vavvas, D., Zhang. X-f. Ras Activation of the Raf Kinase: Tyrosine Kinase recruitment of the MAP Kinase Cascade. Recent Prog Horm. Res. 55, 127-155, 2001.
6. Avruch, J. The Molecular Basis of Insulin Action and Insulin Resistance. In The Genetics of Diabetes Mellitus. Wm. Lowe, ed. Kluwer Academic Publ. 2001, pp133-190.
7. Avruch, J., Belham, C.B., Weng, Q-P, Hara, K., Yonezawa, Y., The p70 S6 Kinase integrates nutrient and growth signals to control translational capacity. Prog. Molec. Subcell. Biol., R.E. Rhoads, ed., Springer 2001 pp 115-154.
8. Tzivion, G., Avruch J., 14-3-3 Proteins: Active Cofactors in Cellular Regulation Serine/ThreoninePhosphorylation. J. Biol. Chem. 2002;277:3061-4.
9. Meigs J.B. Avruch J., The Metabolic Syndrome. Endocrinology Rounds, 2003;2:Issue 5, May. (www.endocrinologyrounds.org)
10. Avruch J., Regulation of Cell Growth and Proliferation in Metazoans by mTOR and the p70 S6 Kinases In The Signaling Handbook, Academic Press.
11. Long X., Müller F., Avruch J., TOR action in mammalian cells and in C. elegans, in TOR, Target of Rapamycin, Current Topics in Microbiology and Immunology, G. Thomas, D.M. Sabatini and M.N. Hall, eds., Springer 2004 pp 115-138.
12. Avruch, J. Hormone Signaling Via Receptor Tyrosine Kinases. Endocrinology, Fifth Edition. DeGroot L.J. and J. L. Jameson, eds., WB Saunders Company, in press.
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