Recent Publications

1. Huynh, K.D. and Lee, J.T. (2003) Inheritance of a pre-inactivated paternal X-chromosome in early mouse embryos. Nature. 18:426

2. O'Neill, L.P., Randall, T.E., Lavender, J., Spotswood, H.T., Lee, J.T., Turner, B.M. (2003) X-linked genes in female embryonic stem cells carry an epigenetic mark prior to the onset of X inactivation. Hum. Molec. Genet. 12:1783-90.

3. Sun, B.K., and Lee, J.T. (2004) X-chromosome inactivation. Chapter in Encyclopedia Reference of Genomics and Proteomics in Molecular Medicine. Springer-Verlag. In press.

4. Lee, J.T. (2003) Functional intergenic transcription: a case study of the X-inactivation centre, Phil Trans. R. Soc. Lond. B 358:1417.

5. Ogawa, Y. and Lee, J.T. (2003) Antisense RNA's in autosomal imprinting and X-chromosome inactivation. Review chapter in special volume of Cytogenet. Genome Res. devoted to "Vertebrate Sex Chromosomes," 99:59-65.

6. Lee, J.T. (2003) Molecular links between X-chromosome inactivation and autosomal imprinting: dosage compensation as an evolutionary impetus for imprinting. Current Biology 13:R242-54.

7. Ogawa, Y. and Lee, J.T. (2003) Xite, X-inactivation intergenic transcription elements that regulate the probability of choice. Mol. Cell, 11:731-743.

8. Shibata, S. and Lee, J.T. (2003) Characterization and quantitation of Tsix transcriptional variants: implications for the mechanism of antisense regulation. Hum. Mol. Genet. 12:125-136.

9. Lee, J.T. (2002) Homozygous Tsix mutant mice reveal a sex-ratio distortion and revert to random X-inactivation. Nature Genet. 32:195-200.

10. Lee, J.T. (2002) "Is X-chromosome inactivation a homology effect?" Review Chapter in Advances in Genetics (Academic Press: ed., Hall, Dunlap & Wu), in press.

11. Chao, W., Huynh, K.D., Spencer, R.J., Davidow, L.S., and Lee, J.T. (2002) CTCF, a candidate Trans-acting factor for X-inactivation choice. Science 295:345-47.

12. Cohen, D.E. and Lee, J.T. (2002) X-chromosome inactivation and the search for chromosome-wide silencers. Curr. Op. Gen. and Dev. 12:219-224.

13. Stavropoulos, N., Lu, N. and Lee, J.T. (2001) A functional role for Tsix transcription in blocking Xist RNA accumulation but not in X-chromosome choice. Proc. Natl. Acad. Sci., USA 98:232-237.

14. Boumil, R. M. and Lee, J.T. (2001) Forty years of decoding the silence in X-chromosome inactivation. Hum. Mol. Genet. 10:2225-32.

15. Huynh, K.D. and Lee, J.T. (2001) Imprinted X-inactivation in eutherians: a model of gametic execution and zygotic relaxation. Curr. Op. Cell Biol. 6:690-97.

16. Lee, J.T. (2000) Disruption of imprinted X-inactivation by parent-of-origin effects at Tsix. Cell 103:17-27.

17. Reizes, B., Lee, J.T., and Leder, P. (2000) Homologous genomic fragments in the mouse pre-T cell receptor alpha (pTa) and Xist loci. Genomics 63:149-52 .

18. Warshawsky, D., Stavropoulos, N., and Lee, J.T. (1999) Further examination of the Xist promoter switch hypothesis in X-inactivation: Evidence against the existence and function of a Po promoter. Proc. Natl. Acad. Sci., USA 96:424-29.

19. Lee, J.T. and Lu, N. (1999) Targeted mutagenesis of Tsix leads to nonrandom X-inactivation. Cell 99:47-57.

20. Lee, J.T., Davidow, L.S., and Warshawsky, D. (1999), Tsix: Identification of a gene antisense to Xist at the X-inactivation center. Nature Genet. 21:400-404.

21. Lee, J.T., Lu, N., and Han, Y. (1999) Genetic analysis of the X-inactivation center reveals an 80 kb multifunctional domain. Proc. Natl. Acad. Sci.,USA 96:3836-3841.