Recent Publications

Grishok A, Pasquinelli AE, Conte D, Li N, Parrish S, Ha I, Baillie DL, Fire A, Ruvkun G, Mello CC. Genes and mechanisms related to RNA interference regulate expression of the small temporal RNAs that control Caenorhabditis elegans developmental timing. Cell 2001; 106:23-34.

Pierce SB, Costa M, Wisotzkey R, Devadhar S, Homburger SA, Buchman AR, Ferguson KC, Heller J, Platt DM, Liu LX, Pasquinelli AE, Doberstein SK, Ruvkun G. Regulation of DAF-2 receptor signaling by human insulin and ins-1, a member of the unusually large and diverse C. elegans insulin gene family. Gene Dev 2001; 15:672-686.

Bürglin TR, Ruvkun G. Regulation of ectodermal and excretory cell function by the C. elegans POU homeobox gene ceh-6 Development 2001; 128:779-790.

Reinhart BJ, Ruvkun G. Isoform-specific mutations in the Caenorhabitis elegans heterochronic gene lin-14 affect stage-specific patterning. Genetics 2001; 157:199-209.

Cahill CM, Tzivion G, Nasrin N, Ogg S, Dore J, Ruvkun G, and M. Alexander-Bridges. M. PI-3 kinase signaling inhibits DAF-16 DNA binding and function via 14-3-3 dependent and independent pathways, J Biol Chem 2001; 276:13402-10.

Wolkow CA, Kimura KD , Lee M, Ruvkun G. C. elegans lifespan is regulated by insulin-like signaling in the nervous system. Science 2000; 290:147-50.

Pasquinelli A, Reinhart B, Slack F , Maller B, Kuroda M, Martindale M., Srinivasan A, Fishman M, Hayward D, Ball E, Degnan, B, Müller P , Spring J, Finnerty J, Corbo J, Levine M, Leahy P , Davidson E, Ruvkun G. Conservation across animal phylogeny of the sequence and temporal expression of the 21 nucleotide let-7 heterochronic regulatory RNA. Nature 2000; 408: 86-89.

Nasri, N, Ogg S, Cahill C, Biggs W, Nui S, Dore J, Calvo D, Shi Y, Ruvkun G, Alexander-Bridges M.. DAF-16 recruits the CBP co activator to the IGFBP-1 promoter in HepG2 cells. Proc Natl Acad Sci USA 2000; 97:10412-7.

Kagoshima H, Sommer R, Reinhart B , Ruvkun G, Cassata G, Bürglin TR. 2000. A graded hypodermal expression of ceh-14 induced by a gonadal signal. Dev Genes Evol 2000; 210:564-569.

Slack FJ, Basson M, Liu Z, Ambros V, Horvitz HR, Ruvkun G. The lin-41 RBCC gene acts in the C. elegans heterochronic pathway between the let-7 regulatory RNA and the lin-29 transcription factor. Mol Cell 2000; 5:659-69.

Reinhart BJ, Slack FA, Basson M, Pasquinelli AE, Bettinger JC, Rougvie AC, Horvitz HR, Ruvkun G. The 21 nucleotide let-7 RNA regulates C. elegans developmental timing. Nature 2000; 403:901-906.

Sze JY, Victor M, Loer C, Shi Y, Ruvkun G. Food and metabolic signaling defects in a C. elegans serotonin null mutant. Nature 2000; 403:560-4.

Tissenbaum HA, Hawdon J, Perregaux M, Hotez P, Guarente L, Ruvkun G. A common muscarinic pathway for diapause recovery in the distantly related nematode species Caenorhabditis elegans and Ancylostoma caninum. Proc Natl Acad Sci USA 2000; 97:460-465.

Sagasti A, Hobert O, Troemel ER, Ruvkun G, Bargmann CI. Alternative olfactory neuron fates are specified by the LIM homeobox gene lim-4. Gene Dev 1999; 13:1794-80

Paradis S, Ailion M, Toker A, Thomas JH, Ruvkun G. A PDK1 homolog is necessary and sufficient to transduce AGE-1 PI3 kinase signals that regulate diapause in C. elegans Gene Dev 1999; 13:1438-1452.

Hobert O, Tessmar K, Ruvkun G. The C. elegans lim-6 LIM homeobox gene regulates neurite outgrowth and function of particular GABAergic neurons. Development 1999; 126:1547-1562.

Hobert O, Moerman DG, Clark KA, Beckerle MC, Ruvkun G. A conserved LIM protein that affects muscular adherens junction integrity and mechanosensory function in Caenorhabditis elegans. J Cell Biol 1999; 144:45-57.

Hobert O, Moerman DG, Clark KA, Beckerle MC, Ruvkun G. A conserved LIM protein that affects muscular adherens junction integrity and mechanosensory function in Caenorhabditis elegans. J Cell Biol 1999; 144: 45-57.

Paradis S, Ruvkun G. Caenorhabditis elegans Akt/PKB transduces insulin receptor-like signals from AGE-1 PI3 kinase to the DAF-16 transcription factor. Gene Dev. 1998; 12:2488-98

Hobert O, Liu Y, DÕAlberti T, Ruvkun G. Control of neural development and function in a thermoregulatory circuit by the LIM homeobox gene lin-11. J Neurosci 1998; 18:2084-2096.

Tissenbaum HA, Ruvkun G. An insulin-like signaling pathway affects both longevity and reproduction in C. elegans. Genetics 1998; 148:703-717.

Ogg S, Paradis S, Gottlieb S, Patterson GI, Lee L, Tissenbaum HA, Ruvkun G. The DAF-16 Fork head-related transcription factor transduces C. elegans insulin-like metabolic and longevity signals. Nature 1997; 389: 994-999.

Kimura KD, Tissenbaum HA, Liu Y, Ruvkun G. daf-2, an insulin receptor-like gene that regulates longevity and diapause in C. elegans. Science 1997; 277: 942-946.

Patterson G, Koweek A, Wong A, Liu Y, Ruvkun G. The DAF-3 Smad protein antagonizes TGF-_-related receptor signalling in the C. elegans dauer pathway. Gene Dev 1997; 11:2679-2690.

Hobert O, Mori I, Yamashita Y, Honda H, Ohshima Y, Liu Y, Ruvkun G. Regulation of interneuron function in the C. elegans thermoregulatory pathway by the ttx-3 LIM homeobox gene. Neuron 1997; 19:345-357.

Sluder AE, Lindblom T, Ruvkun G. An early patterning function for the C. elegans nuclear hormone receptor gene nhr-2. Dev Biol 1997; 184:303-319.

Sze JY, Liu Y, Ruvkun G. VP16-activation of the C. elegans neural specification transcription factor UNC-86 suppresses mutations in downstream genes and causes defects in neural migration and axon outgrowth. Development 1997; 124:1159-1168.

Ha I, Wightman B, Ruvkun G. A bulged lin-4/lin-14 RNA duplex is sufficient for Caenorhabditis elegans Lin-14 temportal gradient formation. Gene Dev 1996; 10:3041-3050.

Barnes TM, Jin Y, Horvitz HR, Ruvkun G, Hekimi S. The C. elegans behavioral gene unc-24 encodes a novel bipartite protein similar to both erythrocyte band 7.2 (stomatin) and non-specific lipid transfer protein (nsLTP). J Neurochem 1996; 67:46-57.

Baumeister R, Liu Y, Ruvkun G. Lineage specific regulators couple cell lineage asymmetry to the transcription of the Caenorhabditis elegans POU gene unc-86 during neurogenesis. Gene Dev 1996; 10:1395-1410.

Morris JZ, Tissenbaum HA, Ruvkun G. A phosphatidylinositol-3-OH kinase family member regulating longevity and diapause in Caenorhabditis elegans. Nature 1996; 382:536-538.