| 1. Insulin control of metabolism, development, and longevity |
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- The genetics of C. elegans hibernation
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- An insulin signaling pathway regulates C. elegans metabolism and longevity
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- Longevity regulation by daf-2
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- Multiple insulin-like probable DAF-2 ligands
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- The AGE-1 PI-3 kinase acts downstream of the DAF-2 insulin receptor
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- C. elegans Akt/PKB Transduces Insulin Receptor-like Signals from AGE-1 PI-3 kinase to the DAF-16 Transcription Factor
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- The C. elegans PTEN homologue DAF-18 acts in the insulin receptor-like metabolic signaling pathway
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- Pathway genetics of the signaling pathway downstream of DAF-2 and parallel to the PDK, AKT pathway.
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- The DAF-16 forkhead protein transduces DAF-2/AGE-1 insulin receptor-like signals
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- Regulation of C. elegans DAF-16 and its human ortholog FKHRL1 by the daf-2 insulin-like signaling pathway
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- A screen for mutations affecting the daf-16/FH-independent daf-2/IR signaling pathway
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| 2. Neural regulation of lifespan and metabolism |
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- C. elegans lifespan is regulated by insulin-like signaling in the nervous system
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- Food and metabolic signaling defects in a C. elegans serotonin synthesis mutant
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- Thermosensory input to endocrine control of metabolism
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- TGF-beta neuroendocrine signal from the ASI dauer regulatory neuron
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- Pheromone Regulation of daf-7expression
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| 3. Downstream of DAF-16 |
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- Genetic and biochemical identification of DAF-16 regulated genes
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- daf-2/ age-1 insulin pathway is involved in osmoregulation
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- Role of cytochrome P450 enzymes in C. elegans development
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- A genetic screen for new players in C. elegans lifespan regulation
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| 4. Heterochronic genes and regulatory RNAs |
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- The molecular dissection of the lin-4/lin-14 RNA duplex
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- Genetic identification of components necessary for lin-14 3’ UTR mediated down-regulation
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- i. A lin-4 allele-specific suppressor screen
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- ii. A screen for trans-acting factors necessary for lin-4/lin-14 3’ UTR regulation
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- Genetic discovery of a second regulatory RNA in the heterochronic pathway
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- Genetic and molecular identification of lin-41 which encodes an RBCC possible RNA binding protein and is down-regulated at the time of let-7 regulatory RNA expression.
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- Conservation across animal phylogeny of the sequence and temporal expression of the 21 nucleotide let-7 heterochronic regulatory RNA
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- Genes and mechanisms related to RNA interference regulate expression of the small temporal RNAs that control C. elegans developmental timing
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- Characterization of the effect of early expression of the small RNA let-7 on developmental timing in C. elegans.
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- Genetics and genomics of heterochronic regulatory RNAs
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- Structure/function studies of let-7 using an in vivo assay of temporal gradient formation
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- Genetic exploration of genes that act upstream or in concert with the heterochronic regulatory RNAs
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- Genetic exploration of transcriptional regulation of let-7 at the L4 and later stages
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- Analysis of the mechanism by which the let-7 and the lin-4 regulatory RNAs regulate expression of target genes
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| 5. The genetics of fat storage |
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| 6. Genetics of molting control |
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| 7. A Genetic Interaction Between a Neurotransmitter Transporter and Synaptobrevin |
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| 8. Conservation of regulatory regions |
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| 9. Life on Mars |
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- SETG, a Search for Extraterrestrial Genomes- A Robotic PCR Detector For Life on Mars Ancestrally Related to Life on Earth
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