People

Laurence G. Rahme, Ph.D. - Principal Investigator

Associate Professor of Surgery, Microbiology and Immunnobiology, Harvard Medical School

Microbiologist, Director of the Molecular Surgical Laboratory, Department of Surgery, Massachusetts General Hospital

rahme at molbio.mgh.harvard.edu | Bio

Current Lab Members

Arunava Bandyopadhaya, Ph.D. - Postdoctoral Fellow

bandyopadhaya at molbio.mgh.harvard.edu

Pseudomonas aeruginosa is a key opportunistic pathogen to the development of severe acute and chronic nasocomial infections in immunocompromised and catheterized patients. I am interested in studying the molecular mechanisms of host-pathogen interactions, in order to develop new strategies for infection prevention and therapy. To this end, I am characterizing small anti-infective compounds and the mechanisms through which they alter the cellular and physiological changes in the immune system by using mouse burn and lung infection models.

Shuangchun "Jeremy" Yan, Ph.D. - Postdoctoral Fellow

yansc at research.mgh.harvard.edu | Curriculum Vitae

My primary research interests are host-microbe interactions, host-pathogen compatibility and susceptibility, and antimicrobials. I am studying the molecular mechanisms behind differences in host susceptibility to infections, using burn and trauma patients as a model. I work with patient data to develop biomarkers for susceptibility to infection, and use Drosophila and mouse infection models to validate human data findings. The goal is to identify patients at high risk of developing infection, and to enable more personalized therapy to potentiate patient immune responses as an anti-infection strategy. I enjoy exploring the city, arts, cooking, and hiking. Additionally, I enjoy coding and am an amateur artist/designer and coded/designed this website.

Damien Maura, Ph.D. - Postdoctoral Fellow

dmaura at research.mgh.harvard.edu

My current work focuses on understanding Pseudomonas aeruginosa's ability to trigger chronic infections that are recalcitrant to both host and antimicrobial therapies. I also work to identify new ways to counter these phenomenona in order to shut down P. aeruginosa virulence/recalcitrance and improve clearance of the pathogen. I am using a combination of molecular biology, chemical biology and various host models to achieve this goal.

Amy Tsurumi, Ph.D. - Postdoctoral Fellow

tsurumi at research.mgh.harvard.edu

My research interest is in elucidating the molecular mechanisms involved in Pseudomonas aeruginosa-host interactions, in particular, the epigenetic and transcriptional modulations that occur as a consequence of acute and chronic infections in Drosophila, mice, and humans. A comprehensive understanding of such mechanisms would contribute to the development of novel therapeutic approaches. Additionally, I am interested in studying malignancies relevant to inflammatory signaling.

Tomoe Kitao-Ando, Ph.D. - Postdoctoral Fellow

kitao at research.mgh.harvard.edu

My current work focuses on the molecular mechanisms of virulence networks in Pseudomonas aeruginosa. I believe that an understanding of the molecular basis of up- or down-regulation of bacterial virulence would contribute to the development of next generation anti-infective agents that could overcome bacterial infections. Outside of the lab, I spend time having fun with my daughter and I love to enjoy ice cream and snow.

Alicia Ballok, Ph.D. - Postdoctoral Fellow

ballok at research.mgh.harvard.edu | Curriculum Vitae

Pseudomonas aeruginosa causes a number of respiratory infections in chronic smokers (COPD), intubated patients (VAP), and individuals with cystic fibrosis (CF). These infections are highly antibiotic resistant, difficult to eradicate, and often lead to death. My research focuses on treating respiratory infections by interfering with the quorum sensing circuitry that regulates group behaviors in P. aeruginosa. Therapies of this type could enhance the efficacy of antibiotic treatments and improve airway function. In my spare time, I enjoy camping, hiking, skiing, attending concerts, visiting museums, and yoga.

Katerina A. Delaveris - Research Coordinator

kdelaveris at partners.org

My interest in research lies in the pathogenesis of bacterial infectious diseases and their relative epidemiological scope. The increasing prevalence of drug-resistant strains of bacteria, along side of the expanding scope of bioengineering, create a growing need for strong biodefense mechanisms. I will be attending Georgetown University in the fall of 2015 for biodefense and counterproliferation of select biological and chemical agents.

George Massey M.A. - Master's Thesis Student/M.D. Student

gmassey1 at mgh.harvard.edu

I am currently working to elucidate host-pathogen interactions and mechanisms of virulence involving Acinetobacter baumannii, which has been identified as a multidrug-resistant, opportunistic pathogen that is increasingly seen in nosocomial infections. I will be attending medical school at Boston University in the fall to become a physician and put some of the basic science that I am learning now into medical practice. During my free time, I like to play soccer and other sports, watch films, read philosophy, do volunteer service, and dance lindy hop.

Mohammad Hadi Gharedaghi, M.D. - Postdoctoral Fellow

mgharedaghi at mgh.harvard.edu

I am currently working on mouse models of infectious diseases and development of new anti-virulence agents for Pseudomonas aeruginosa and Acinetobacter baumannii . Part of my research includes characterizing the mode of invasion of intestinal epithelial cells by E. coli ; both in-vivo and in-vitro. Following my work here, I will be completing my surgical residency at The Masonic Medical Center in Chicago, Illinois.

Alumni in Chronological Order

  • Name
  • Current Position
  • Hui Cao, Ph.D.
  • Senior Scientist Aventis Pharma - Recipient of Damon Runyon Research Fellowship
  • Gee Lau, Ph.D.
  • Assistant Professor, Department of Pathobiology, University of Illinois at Urbana-Champaign
  • Boyan Goumnerov, MD
  • Vice President, Clinical Operations, Fluro Pharma
  • Regina Baldini, Ph.D.
  • Assistant Professor of Biochemistry - Instituto de Química USP, University of São Paulo, Brasil - Recipient of Brazilian FAPESP Research Fellowship
  • Gomathi Khrishan, Ph.D.
  • Senior Research Associate, Spaulding Rehabilitation Hospital
  • Gaoping Xiao, Ph.D
  • Department of Molecular, Cellular and Developmental Biology, Yele University
  • Eric Déziel, Ph.D
  • Assistant Professor, INRS-Institut - Recipient of Canadian - Armand-Frappier NRC Research Fellowship
  • Kathleen Padfiled, MD
  • Anesthesiologist, Stepping Hill Hospital, Manchester UK
  • Suresh Gopalan, Ph.D.
  • CEO & Founder, ReSurfX
  • Jeremy Goverman, MD
  • Duke University, Plastic Surgery Fellow
  • Dingding An, Ph.D
  • Channing Laboratory, Brigham and Women's Hospital
  • Melissa Starkey, Ph.D
  • Clinical Guidlines Senior Administrator, American College of Physicians
  • Panayiotis Panopoulos, Ph.D
  • European Community Examiner Hospital Policy Compliance, Brussels, Belgium
  • Aikaterini Konstantinou
  • European Community Head Examiner, Drug Development, Brussels, Belgium
  • Maya Khezam
  • Ph.D Candidate, UPEN
  • Yok-Ai Que, MD, Ph.D.
  • Maître d'Enseignement et de Recherche (MER), Department of Fundamental Microbiology, University of Lausanne
  • Jianxin He, Ph.D.
  • Director of Molecular Biology, Assay Biotechnology, Inc.
  • Ronen Hazan, Ph.D.
  • Assistant Professor of Biology, University of Jerusalem, Israel
  • Viktor Schneidt
  • Graduate Student at Institut für Mikrobiologie und Biotechnologie, Ulm University, Ulm, Germany


Note: Lab alumni who wish to update their information, please email Katerina: kdelaveris(at)partners.org