Center for Computational & Integrative Biology, Massachusetts General Hospital
Department of Molecular Biology, Massachusetts General Hospital
Department of Genetics, Harvard Medical School
Howard Hughes Medical Institute

  Jack W. Szostak
Investigator, Howard Hughes Medical Institute
Professor, Department of Genetics, Harvard Medical School
Alex. A. Rich Distinguished Investigator, Department of Molecular Biology, Massachusetts General Hospital

szostak@molbio.mgh.harvard.edu

  Katarzyna Adamala - Student
University of Warsaw

Research: Prebiotic synthesis of lipid and nucleotide derivatives.
  Tony Bell - Post-doc
Ph.D., New York University
Experimental Analysis of Helical Protein Stability with Neville R. Kallenbach

Research: Engineering of Elongation Factor Tu (EF-Tu)

tbell@molbio.mgh.harvard.edu
  J. Craig Blain - Graduate Student, BBS Program
B.Sc.H., Biochemistry, Queen's University, Kingston, Canada

Research: Synthesis of non-natural nucleic acids; Darwinian evolution in artificial chemical systems

jcblain@fas.harvard.edu
  Raphael Bruckner - Graduate Student, BBS Program
A.B., Columbia University

Research: RNA polymerase ribozyme selection; monodisperse vesicle production; clonal expansion of vesiclar populations

bruckner@fas.harvard.edu
  Itay Budin - Graduate Student, MCB Program
B.S., Biological Engineering, Cornell University

Research: Evolutionary biophysics

ibudin@fas.harvard.edu
  Xin Cai - Undergraduate Student, Chemistry and Physics, Harvard

Research: Synthesis of non-natural nucleic acids. The non-enzymatic, template dependent replication of GNA.

xcai@fas.harvard.edu
  Jingyang (Jesse) Chen - Post-doc
Ph.D., Massachusetts Institute of Technology
DNA cleavage and structural studies of duplex DNA with JoAnne Stubbe

Research: Artificial DNAs for non-enzymatic polymerization and aptamer selection

jesse.chen@molbio.mgh.harvard.edu
  Quentin Dufton - Graduate Student, Molecular and Cellular Biology
Hon. B.Sc. Immunology, University of Toronto

Research: Protocells

qdufton@mcb.harvard.edu
  Mark Elenko - Graduate Student, BBS Program
A.B., Columbia University; M.S., New York University

Research: Distribution of aptamer functionality; Single-molecule techniques

mark_elenko@student.hms.harvard.edu
  Ben Heuberger - Post-doc
Ph.D., UC Riverside

Research: Development of protocell actualization through enhancement of nonenzymatic nucleic acid information-transfer efficacy.

heuberger@molbio.mgh.harvard.edu
  Mathangi Krishnamurthy - Post-doc
Ph.D., U. of Tennessee Health Science Center
Novel agonists and antagonists for cannabinoid receptors with Bob M. Moore II

Research: Synthesis of 3' amino substituted 5' phosphoimidazolide derivatives of deoxyribose

mathangi@molbio.mgh.harvard.edu
  Chi-Wang Lin - Post-doc
Ph.D., MIT

Research: Unnatural peptides and their applications in controlling protein-protein interactions that have potential medical value.

cwlin@molbio.mgh.harvard.edu
  Alonso Ricardo - Post-doc
Ph.D., University of Florida
Bioorganic molecules in the cosmos and the origin of Darwinian molecular systems with Steven Benner

Research: mRNA display as a tool for the discovery of new antibiotics, bioorganic chemistry and to study the origins of life
  Yollete V. Guillen Schlippe - Post-doc
Ph.D. Biochemistry, Brandeis University
Enzymology of IMPDH (inosine 5'monophosphate dehydrogenase) with Liz Hedstrom

Research: Ribosomal synthesis of highly modified peptides-reassigniment of codons to expand the genetic code

guillen@molbio.mgh.harvard.edu
  Jason P. Schrum - Graduate Student, BBS Program
B.S. Cellular and Molecular Biology & B.M.A Harpsichord, University of Michigan

Research: Phosphoramidate Nucleic Acids; Chemical Nucleic Acid Replication; Genomics of protocells

schrum@molbio.mgh.harvard.edu
  Pam Svec - HHMI Lab Manager


svec@frodo.mgh.harvard.edu
  Sylvia Tobé - Graduate Student, France
Undergraduate degree, J. Fourier University, Grenoble; Master’s degree, Pierre and Marie Curie University, Paris

Research: Phosphoramidate DNA chemical primer extension

tobe@fas.harvard.edu
  Simon Trevino - Graduate Student, BBS Program
B.S., Biology, University of Texas at San Antonio

Research: Selection studies of nucleic acid polymers generated from mutant polymerase

strevino@fas.harvard.edu
  Na Zhang - Post-doc
Ph.D., Cornell U. Medical School
NMR Structural Determination of Guanine-Rich Oligonucleotides and DNA Adducts with Dinshaw Patel

Research: Unnatural nucleic acid folding structure and fatty acid permeabilty using NMR

Na.Zhang@molbio.mgh.harvard.edu
  Shenglong Zhang - Post-doc
Ph.D., Columbia University

Research: Design and synthesis of self-replicating nucleotides for enzyme tree primer extension reaction with the aim of constructing a replicating model protocell capable of spontaneous Darwinian evolution.
  Ting F. Zhu - Graduate Student, HST (MEMP) Program
M.S. Mechanical Engineering, MIT

Research: Protocell division mechanisms

tzhu@mit.edu

General Contact Information:

CCIB 7215
Simches Research Center
185 Cambridge Street
Boston, Massachusetts 02114

FAX: 617-643-3328
Lab Manager Phone: 617-726-5102

 

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