Center for Computational & Integrative Biology, Massachusetts General Hospital
Department of Molecular Biology, Massachusetts General Hospital
Department of Genetics, Harvard Medical School
Howard Hughes Medical Institute

  Jack W. Szostak
Investigator, Howard Hughes Medical Institute
Professor, Department of Genetics, Harvard Medical School
Alex. A. Rich Distinguished Investigator, Department of Molecular Biology, Massachusetts General Hospital

szostak@molbio.mgh.harvard.edu

  Katarzyna Adamala - Student
University of Warsaw

Research: Prebiotic synthesis of lipid and nucleotide derivatives.
  Tony Bell - Post-doc
Ph.D., New York University
Experimental Analysis of Helical Protein Stability with Neville R. Kallenbach

Research: Engineering of Elongation Factor Tu (EF-Tu)

tbell@molbio.mgh.harvard.edu
  Raphael Bruckner - Graduate Student, BBS Program
A.B., Columbia University

Research: RNA polymerase ribozyme selection; monodisperse vesicle production; clonal expansion of vesiclar populations

bruckner@fas.harvard.edu
  Xin Cai - Undergraduate Student, Chemistry and Physics, Harvard

Research: Artificial DNAs
  Jingyang (Jesse) Chen - Post-doc
Ph.D., Massachusetts Institute of Technology
DNA cleavage and structural studies of duplex DNA with JoAnne Stubbe

Research: Artificial DNAs for non-enzymatic polymerization and aptamer selection

jesse.chen@molbio.mgh.harvard.edu
  Quentin Dufton - Graduate Student, Molecular and Cellular Biology
Hon. B.Sc. Immunology, University of Toronto

Research: Protocells

qdufton@mcb.harvard.edu
  Mark Elenko - Graduate Student, BBS Program
A.B., Columbia University; M.S., New York University

Research: Distribution of aptamer functionality; mixed nucleic acid selections

mark_elenko@student.hms.harvard.edu
  Janet Iwasa - Post-doc
Ph.D., Biochemistry, UCSF

Project: 3D molecular visualizations of the origins of life (in collaboration with the Museum of Science)

jiwasa@gmail.com
  Mathangi Krishnamurthy - Post-doc
Ph.D., U. of Tennessee Health Science Center
Novel agonists and antagonists for cannabinoid receptors with Bob M. Moore II

Research: Synthesis of 3' amino substituted 5' phosphoimidazolide derivatives of deoxyribose

mathangi@molbio.mgh.harvard.edu
  Chi-Wang Lin - Post-doc
Ph.D., MIT

Research: Unnatural peptides and their applications in controlling protein-protein interactions that have potential medical value.

cwlin@molbio.mgh.harvard.edu
  Alexander (Sasha) Litovchick - Post-doc
Ph.D., Weizmann Institute
Aminoglycoside-arginine conjugates as novel HIV Tat antagonists with Aviva Lapidot

Research: Replicase selection; catalysis of RNA polymerization

sasha@molbio.mgh.harvard.edu
  Abhijit Patel - Post-doc
Ph.D., M.D., Yale University
Splicing of minor-class introns with Joan A. Steitz

Research: 2'O-methyl RNA aptamer selections

aapatel@partners.org
  Alonso Ricardo - Post-doc
Ph.D., University of Florida
Bioorganic molecules in the cosmos and the origin of Darwinian molecular systems with Steven Benner

Research: mRNA display as a tool for the discovery of new antibiotics, bioorganic chemistry and to study the origins of life
  Mui Sam - Post-doc
Ph.D., UCLA
Mechanistic studies on chemical and biological nucleases with Mahdi M. Abu-Omar and Guillaume F. Chanfreau

Research: Characterization of phosphoramidate DNA

mui@molbio.mgh.harvard.edu
  Yollete V. Guillen Schlippe - Post-doc
Ph.D. Biochemistry, Brandeis University
Enzymology of IMPDH (inosine 5'monophosphate dehydrogenase) with Liz Hedstrom

Research: Ribosomal synthesis of highly modified peptides-reassigniment of codons to expand the genetic code

guillen@molbio.mgh.harvard.edu
  Jason P. Schrum - Graduate Student, BBS Program
B.S. Cellular and Molecular Biology & B.M.A Harpsichord, University of Michigan

Research: Replicase selection

schrum@molbio.mgh.harvard.edu
  Florian P. Seebeck - Post-doc
Ph.D., ETH-Zurich
Enzyme engineering with D. Hilvert

Research: Selection of peptides with post-translational modifications

seebeck@molbio.mgh.harvard.edu
  Burckhard Seelig - Post-doc
Ph.D., Freie University, Berlin
Ribozyme Evolution with Andres Jaschke

Research: Searching protein sequence space for novel enzymatic functions

seelig@molbio.mgh.harvard.edu
  Lele Sun - Post-doc
Ph.D., UMASS-Medical School
Peptidyl-transferase ribozyme selections with Biliang Zhang

Research:Isothermal DNA replication

lsun@molbio.mgh.harvard.edu
  Pam Svec - HHMI Lab Manager


svec@frodo.mgh.harvard.edu
  Sylvia Tobé - Graduate Student, France
Undergraduate degree, J. Fourier University, Grenoble; Master’s degree, Pierre and Marie Curie University, Paris

Research: Phosphoramidate DNA chemical primer extension

tobe@fas.harvard.edu
  Douglas A. Treco - Assistant in Molecular Biology
Ph.D. Biochemistry and Molecular Biology, SUNY at Stony Brook
with Norm Arnheim

Research: Nonenzymatic replication of nucleic acids

treco@molbio.mgh.harvard.edu
  Simon Trevino - Graduate Student, BBS Program
B.S., Biology, University of Texas at San Antonio

Research: Selection studies of nucleic acid polymers generated from mutant polymerase

strevino@fas.harvard.edu
  Ching-Hsuan Tsai - Post-doc
Ph.D., Carnegie Mellon University
Design and Engineering Recombinant Hemoglobin as Potenial Hemoglobin based Oxygen Carriers with Chien Ho

Research: TNA/Protein engineering a Reverse Transcriptase

tsai@molbio.mgh.harvard.edu
  Na Zhang - Post-doc
Ph.D., Cornell U. Medical School
NMR Structural Determination of Guanine-Rich Oligonucleotides and DNA Adducts with Dinshaw Patel

Research: Unnatural nucleic acid folding structure and fatty acid permeabilty using NMR

Na.Zhang@molbio.mgh.harvard.edu
  Ting F. Zhu - Graduate Student, HST (MEMP) Program
M.S. Mechanical Engineering, MIT

Research: Protocell division mechanisms

tzhu@mit.edu
  Keyong Zou - Post-doc
Ph.D., Texas A&M University
Photochemistry and signal transduction with Hagan Bayley

Research: Chemical synthesis of TNA monomers; TNA selection

zou@molbio.mgh.harvard.edu

General Contact Information:

CCIB 7215
Simches Research Center
185 Cambridge Street
Boston, Massachusetts 02114

FAX: 617-643-3328
Lab Manager Phone: 617-726-5102

 

|| research || people || publications || movies || resources || join ||